Topical Dexamethasone and Tacrolimus for the Treatment of Oral Chronic Graft-Versus-Host Disease

Completed · Phase 2

Conditions studied: Oral Chronic Graft-versus-host Disease

In brief

The purpose of this research study is to determine the effectiveness of topical steroid therapy (with a drug called dexamethasone) and topical tacrolimus therapy for the treatment of oral chronic Graft-Versus-Host Disease (cGVHD)

Key facts

Study ID

NCT00686855

Run by

Brigham and Women's Hospital

People needed

46

Starts

2008-08-01

Expected to finish

2013-03-01

Last updated by the study team

2014-03-20

Who can join

Age: 4 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with oral chronic graft-versus-host disease
• Patients 4 years of age or older
• Stable cGVHD medication regimen for the four weeks prior to study enrollment

You may not qualify if…

• Patients already on topical steroid or tacrolimus therapies

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Children's Hospital Boston — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Beth-Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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