Hypothalamic Functional Magnetic Resonance Imaging (fMRI) Response to Nutrients

Completed · Phase 2

Conditions studied: Obesity

In brief

The purpose of this study is to identify how certain parts of the brain that control appetite respond to changes in dietary carbohydrate and fat.

Key facts

Study ID

NCT00686608

Run by

Oregon Health and Science University

People needed

56

Starts

2006-10-01

Expected to finish

2015-07-01

Last updated by the study team

2019-08-07

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 year to 45 years of age
• BMI 18 to 25 kg/m2 (25 subjects) and 30 to 40 kg/m2 (25 subjects), matched for age and sex.
• At maximal lifetime weight.
• Weight stable for at least 3 months.

You may not qualify if…

• Those with a major medical illness or who require prescription medication, including: cancer, coronary artery disease, hypertension, and diabetes.
• Subjects taking psychiatric or centrally-acting (CNS) medications, or who are diagnosed with a psychiatric or neurological illness, including: depression, anorexia, bulimia, and seizure disorder.
• Subjects who have lost weight as a result of dieting, pharmacological treatment, or bariatric surgery.
• Weight > 350 lbs or girth > 60 inches (the limits of the MR machine)
• Exercise > 30 minutes, 3 times a week.
• Alcohol consumption > 2 drinks / day.
• Weight > 300 lbs (150 kg) (weight limit for MR machine).
• Blood glucose > 100 mg/dL, abnormal creatinine or liver function tests.
• Illicit drug use.
• Pregnancy.
• Extreme dietary habits as determined by a GCRC nutritionist: very high or low dietary carbohydrate, protein, or fat intakes.
• Those with a contraindication to exposure to strong magnetic fields: presence of metal in the body such as body piercing, shrapnel, cardiac pacemakers or aneurysm clips.
• Those with claustrophobia.

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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