S0713: Oxaliplatin, Capecitabine, Cetuximab, and RT Followed By Surgery in Pts W/Stage II or III Rectal Cancer
Completed · Phase 2
Conditions studied: Colorectal Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving chemotherapy and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying the side effects and how well giving oxaliplatin, capecitabine, and cetuximab together with radiation therapy followed by surgery works in treating patients with stage II or stage III rectal cancer.
Key facts
- Study ID
- NCT00686166
- Run by
- SWOG Cancer Research Network
- People needed
- 83
- Starts
- 2009-02-01
- Expected to finish
- 2018-03-01
- Last updated by the study team
- 2018-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Cancer Center at UMC Orange Grove — Tucson, Arizona, United States
- Arizona Cancer Center at University Medical Center North — Tucson, Arizona, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Sutter Health - Western Division Cancer Research Group — Novato, California, United States
- Desert Regional Medical Center Comprehensive Cancer Center — Palm Springs, California, United States
- Sutter Cancer Center at Roseville Medical Center — Roseville, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- California Pacific Medical Center - California Campus — San Francisco, California, United States
- Sutter Pacific Medical Foundation — Santa Rosa, California, United States
- Sutter Solano Medical Center — Vallejo, California, United States
- Memorial Hospital Cancer Center - Colorado Springs — Colorado Springs, Colorado, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- Regional Cancer Center at Memorial Medical Center — Springfield, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Reid Hospital & Health Care Services — Richmond, Indiana, United States
- Cancer Center of Kansas, PA - Chanute — Chanute, Kansas, United States
- Cancer Center of Kansas, PA - Dodge City — Dodge City, Kansas, United States
- Cancer Center of Kansas - Fort Scott — Fort Scott, Kansas, United States
- Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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