Prolotherapy Versus Steroids for Thumb Carpo-metacarpal Joint Arthritis

Stopped early · Not applicable

Conditions studied: Thumb Carpometacarpal Joint Osteoarthritis

In brief

Arthritis of the base of the thumb is a common debilitating problem. It is believed that laxity (loosening) of the joint leads to worsening arthritis in this joint. This can be treated by securing the joint surgically or symptoms can be treated with hand therapy and/or injection of corticosteroids. Recently prolotherapy (sugar water) has been shown to decrease looseness of joints and also be helpful for hand and knee arthritis. We hypothesize that prolotherapy injections for thumb arthritis will be equally or more beneficial to the patients than steroids.

Key facts

Study ID

NCT00685880

Run by

Mayo Clinic

People needed

2

Starts

2008-05-01

Expected to finish

2010-07-01

Last updated by the study team

2012-08-30

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age >45
• Ability to make follow-up visits over the 6 month protocol
• Ability to give informed consent
• Eaton grade 2-3 thumb carpo-metacarpal joint osteoarthritis with pain over 3/10 on visual analogue scale with symptoms present greater then 6 months.

You may not qualify if…

• Recent trauma to the hand or wrist or fractures eeen on radiographs
• Eaton grade 1, or 4 joints affected
• Metabolic bone disease
• Recent systemic or localized infection (within last 2 weeks)
• History of rheumatologic disease
• Allergies to injected solutions
• Thumb carpo-metacarpal joint injections in the prior 6 months.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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