Comparison of Airway Clearance Therapy in Cystic Fibrosis Using the Same VEST Therapy Device But With Different Settings
Completed · Phase 4
Conditions studied: Cystic Fibrosis
In brief
Our primary hypothesis is that airway clearance therapy with sine waveform HFCWO using higher inflation pressures combined with both low and high oscillator frequencies will result in greater sputum production compared to sine waveform HFCWO with lower inflation pressures and mid-frequency oscillations.
Key facts
- Study ID
- NCT00685035
- Run by
- University of Minnesota
- People needed
- 17
- Starts
- 2008-05-01
- Expected to finish
- 2008-10-01
- Last updated by the study team
- 2016-07-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of CF established by sweat chloride > 60 mmol/L.
- Age older than 18 years.
- History of chronic daily sputum production.
- Currently on a home therapeutic regimen that includes some form of airway clearance performed with a HFCWO device at least once daily that also includes concomitant use of an inhaled mucolytic and inhaled bronchodilator.
- FVC and FEV1 > 40%-predicted, and with stable lung function (no greater than a 10% variation in lung function parameters over the preceding 3 months).
- Evaluated at the University of Minnesota CF Center 3 or more times in the preceding 12 months.
You may not qualify if…
- Hospitalization for CF pulmonary complications in the 2 months preceding enrollment.
- Hemoptysis > 60 cc in a single episode in the 4 weeks preceding enrollment.
- Chest pain requiring use of narcotic for pain control.
- Current participation in another clinical trial.
- Use of intravenous antibiotics for CF respiratory complications in the 2 months preceding enrollment.
- No prior experience using HFCWO devices for airway clearance
Where it is running
- University of Minnesota Medical Center — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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