Insulin and Polycystic Ovary Syndrome

Completed · Not applicable

Conditions studied: PCOS

In brief

Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin directly by inhibition of islet insulin release with diazoxide in obese women with PCOS 1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.

Key facts

Study ID

NCT00683774

Run by

Virginia Commonwealth University

People needed

21

Starts

2005-11-01

Expected to finish

2008-12-01

Last updated by the study team

2017-06-14

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Obese women with PCOS and normal women aged 18-40,
• PCOS less than 8 periods/year, elevated total or free testosterone, normal thyroid function tests and serum prolactin, exclusion of adrenal hyperplasia
• Normal regular monthly periods, no clinical evidence of androgen excess,
• All Acceptable health on interview, medical history, physical exams and lab tests, signed, witnessed informed consent and ability to comply to study requirements

You may not qualify if…

• DM, clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic or malignant disease.

Where it is running

• General Clinical Research Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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