T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies
Completed · Phase 2
Conditions studied: Acute Myelogenous Leukemia, Lymphoid Leukemia, Chronic Myelogenous Leukemia, Malignant Lymphoma, Hodgkin's Disease, Chronic Lymphocytic Leukemia, Myeloproliferative Disorder, Anemia, Aplastic, Myelodysplastic Syndromes
In brief
Objectives: 1. To evaluate disease free survival after Campath 1H-based in vivo T-cell depletion and non-myelo-ablative ablative stem cell transplantation in patients with hematologic malignancies. 2. To evaluate the incidence and severity of acute and chronic GVHD after Campath 1H-based in vivo T-cell depletion, in patients with hematologic malignancies undergoing non-myelo-ablative stem cell transplantation. 3. To evaluate engraftment and chimerism after Campath 1H-based in vivo T-cell depletion and non-myelo-ablative ablative stem cell transplantation in patients with hematologic malignancies.
Key facts
- Study ID
- NCT00683046
- Run by
- University of Chicago
- People needed
- 204
- Starts
- 2001-11-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2016-11-22
Who can join
Age: any, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Zubrod performance status 2 (See Appendix B).
- Life expectancy is not severely limited by concomitant illness.
- Adequate cardiac and pulmonary function. Patients with decreased LVEF or PFTS will be evaluated by cardiology or pulmonary prior to enrollment on this protocol.
- Serum creatinine <1.5 mg/dL or Creatinine Clearance >50 ml/min .
- Serum bilirubin 2.0 mg/dl, SGPT <3 x upper limit of normal
- No evidence of chronic active hepatitis or cirrhosis.
- HIV-negative
- Patient is not pregnant
- Patient or guardian able to sign informed consent.
You may not qualify if…
- N/A
Where it is running
- The University of Chicago — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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