Autonomic Function in Obstructive Sleep Apnea
Completed · Not applicable
Conditions studied: Obstructive Sleep Apnea
In brief
The purpose of this study is to determine if obstructive sleep apnea (OSA) causes autonomic dysfunction independent of its effects on hyperglycemia.
Key facts
- Study ID
- NCT00681161
- Run by
- Vanderbilt University
- People needed
- 70
- Starts
- 2006-03-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2017-02-24
Who can join
Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 21-80.
- BMI between 25 and 35.
- Symptoms strongly indicative of sleep apnea (loud snoring, witnessed apneas or history of OSA based on laboratory PSG within 3 months of screening, not currently using CPAP, oral appliances or other treatments for OSA)
You may not qualify if…
- History of previous treatment for OSA.
- History of diabetes.
- History of other disorders known to affect autonomic function (e.g. Parkinson's disease, peripheral neuropathy of any cause, or requiring medications known to affect autonomic function that cannot be stopped safely for 48 hours).
- No evidence of peripheral neuropathy on examination, negative laboratory tests for common causes of neuropathy (B12, Thyroid stimulating hormone, serum protein electrophoresis).
- Inability to cooperate with testing, or to undergo testing (individuals with irregular heart rhythms, significant lung disease, previous LASIK procedure, unable to stop hypertensive medications for 48 hours).
- Medications affecting glucose levels, hypoglycemic agents, high dose thiazide diuretics, beta blocking agents.
- Pregnant or lactating females.
Where it is running
- Vanderbilt University — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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