Nitrofurantoin and Urinary Tract Infections (UTIs)

Stopped early · Not applicable · Has a placebo group

Conditions studied: Urinary Tract Infections

In brief

Urinary tract infection (UTI) is the most common complication after surgery for prolapse or urinary incontinence. UTIs are painful and have the potential to turn into kidney infections. We are asking women who self-catheterize after surgery to try either an antibiotic or a placebo pill so we can see if we can prevent UTIs without causing side effects. This study will not require any additional visits or blood draws. You will be asked to answer some questions, keep a brief diary of your experience, and immediately report any symptoms of a UTI to your doctor.

Key facts

Study ID

NCT00678041

Run by

University of Pittsburgh

People needed

10

Starts

2008-05-01

Expected to finish

2009-05-01

Last updated by the study team

2016-09-27

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women who fail a post-operative voiding trial and are willing to learn clean intermittent self-catheterization (CISC) prior to discharge from the hospital

You may not qualify if…

• Known drug allergy to nitrofurantoin
• A history of renal insufficiency
• Renal transplant
• Renal nephropathy
• A recent history of more than 3 Urinary Tract Infections (UTIs) per year
• Known immunocompromised condition (organ transplant, chemotherapy for cancer or arthritis, autoimmune diseases (lupus etc)).

Where it is running

• Magee Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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