Pharmacokinetic and Efficacy Study of Nordihydroguaiaretic Acid (NDGA) in Non Metastatic Recurrent Prostate Cancer

Stopped early · Phase 2

Conditions studied: Prostate Cancer

In brief

This is a Phase II, single center study measuring the pharmacokinetic parameters of NDGA administration and assessing the proportion of patients who experience a 50% decline in PSA.

Key facts

Study ID

NCT00678015

Run by

University of California, San Francisco

People needed

12

Starts

2008-05-01

Expected to finish

2011-06-01

Last updated by the study team

2014-04-09

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Rising prostate-specific antigen (PSA) value after local therapy with a PSA doubling time (PSADT) between 6 and 24 months (four or more readings at least two weeks apart within the last six months)
• Prior definitive therapy for prostate cancer consisting of one of the following:
• External beam radiotherapy with or without hormone therapy
• Brachytherapy with or without pelvic external beam radiation or hormone therapy
• Radical prostatectomy with or without adjuvant or salvage radiation therapy
• PSA > 1 ng/ml, which has risen serially on two determinations at least one week apart
• Progressive disease by "Phoenix" consensus definition for patients who have undergone primary radiation therapy (PSA nadir + 2 ng/mL)
• No metastatic disease
• Prior adjuvant or neoadjuvant androgen deprivation is permitted, provided:
• > 6 months since last day of effective androgen deprivation
• Testosterone > 250 ng/dL
• Patient is not on intermittent androgen deprivation
• Karnofsky performance status (KPS) of > 70%
• Liver Function Tests are within normal range
• Glycated hemoglobin (HgA1c) < 6%
• Patients must be four weeks from major surgery or radiotherapy to be eligible

You may not qualify if…

• Presence of another active malignancy other than prostate cancer, or treated squamous/basal cell carcinoma of the skin. Concomitant medical condition which would make it undesirable, in the physician's opinion, for the patient to participate in the protocol or would jeopardize compliance with the protocol requirements
• Diabetes mellitus, unless diet-controlled
• Must be off saw palmetto, pomegranate juice, finasteride, or any herbal agent intended to lower PSA for > 4 weeks. Baseline PSADT calculation must occur off of these agents
• Patients may not have evidence of local-only recurrence of prostate cancer
• No history of liver disease, including Hepatitis B or C, alcoholic liver disease, or autoimmune liver disease. A prior history of Hepatitis A is allowed provided that baseline liver function tests are within normal limits
• Patients with castration resistant prostate cancer are ineligible (prostate cancer which has progressed on androgen deprivation therapy with a Luteinizing hormone-releasing hormone (LHRH)-agonist or orchiectomy)

Where it is running

• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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