Statin Therapy in the Treatment of Sepsis

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Septic Shock

In brief

Simvastatin will attenutat IL-6 levels and lead to a more rapid shock reversal than placebo

Key facts

Study ID

NCT00676897

Run by

Beth Israel Deaconess Medical Center

People needed

18

Starts

2008-02-01

Expected to finish

2010-12-01

Last updated by the study team

2017-06-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Greater than 18 years old
• Hypotensive requiring vasopressors
• Suspected Infection

You may not qualify if…

• Pregnant
• Liver Failure (ALT or AST > 120)
• Rhabomyolysis (CPK > 3x normal)
• Comfort care measures status
• Chronic Liver Disease (Cirrhosis)
• Use of Cyclosporin, Digoxin, Statins
• Patients who are unable to take medications by mouth or NGT

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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