A Safety and Efficacy Study of Oral Dimebon in Patients With Mild-To-Moderate Alzheimer's Disease

Completed · Phase 3 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

The Connection Study is a six-month confirmatory Phase 3 study to determine the safety and efficacy of Dimebon in the treatment of mild-to-moderate Alzheimer's disease (AD).

Key facts

Study ID

NCT00675623

Run by

Medivation, Inc.

People needed

598

Starts

2008-05-01

Last updated by the study team

2016-09-27

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mild-to-Moderate Alzheimer's disease
• Probable AD (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV)
• MMSE score 10-24 inclusive
• Computerized tomography (CT) san or magnetic resonance imaging (MRI) consistent with AD
• Caregiver who cares for the patient at least 5 days per week

You may not qualify if…

• Anti-dementia drugs including cholinesterase-inhibitors or N-methyl-D-aspartate receptor (NMDA) receptor antagonists within 90 days
• Other causes of dementia
• Other primary psychiatric or neurological disorders
• Unstable medical illnesses or significant hepatic or renal disease

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Costa Mesa, California, United States
• Study site — Fresno, California, United States
• Study site — Rancho Mirage, California, United States
• Study site — Hamden, Connecticut, United States
• Study site — New Haven, Connecticut, United States
• Study site — Norwalk, Connecticut, United States
• Study site — Hallandale, Florida, United States
• Study site — Hialeah, Florida, United States
• Study site — Miami, Florida, United States
• Study site — North Miami, Florida, United States
• Study site — Sunrise, Florida, United States
• Study site — West Palm Beach, Florida, United States
• Study site — Indianapolis, Indiana, United States
• Study site — Paducah, Kentucky, United States
• Study site — Newton, Massachusetts, United States
• Study site — Ann Arbor, Michigan, United States
• Study site — St Louis, Missouri, United States
• Study site — Brooklyn, New York, United States
• Study site — Cedarhurst, New York, United States
• Study site — New York, New York, United States
• Study site — Rochester, New York, United States
• Study site — Staten Island, New York, United States
• Study site — Morganton, North Carolina, United States
• Study site — Centerville, Ohio, United States

Full record on ClinicalTrials.gov

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