Linkage Analysis in Interstitial Cystitis

Completed

Conditions studied: Prostatitis, Cystitis, Interstitial, Urinary Bladder, Overactive, Chronic Pelvic Pain Syndrome, Painful Bladder Syndrome

In brief

Urologic pelvic pain syndrome (UCPPS), variably termed painful bladder syndrome/interstitial cystitis (PBS/IC) in females and chronic prostatitis/chronic pelvic pain syndrome in men (CP/CPPS), is a chronic, debilitating clinical syndrome presenting as severe pelvic pain with extreme urinary urgency and frequency in the absence of any known cause. The etiologic mechanisms underlying UCPPS are unknown, but recurrence, risks to siblings of affected individuals, concordance among monozygotic twins, and our own preliminary studies indicate a strong genetic contribution to the cause of UCPPS. The overall goal of this proposal is use novel approaches to understand the basis of UCPPS, to identify candidate genes containing mutations that result in UCPPS and determine how the different encoded proteins of these genes interact with one another in a common biological pathway. Ultimately, understanding how mutations in at least five different genes yield the symptoms of UCPPS should lead to improved diagnosis and possible therapies.

Key facts

Study ID

NCT00675298

Run by

Beth Israel Deaconess Medical Center

People needed

300

Starts

2006-01-01

Expected to finish

2011-06-01

Last updated by the study team

2017-02-03

Who can join

Age: 3 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Have symptoms for at least 3 months within the preceding 6 months:
• Pain in the pelvic area
• Urinary frequency and/or
• Urinary urgency and/or
• Sexual dysfunction (erectile dysfunction)
• Have CP/CPPS, IC, PBS, or BFS
• Be willing to provide a saliva and urine sample
• Agree to complete several brief questionnaires
• Family of someone with CP/CPPS, PBS, IC or BFS
• Live in the USA or Canada

You may not qualify if…

• Major structural/anatomical urinary tract abnormalities
• Underlying inborn or congenital conditions

Where it is running

• Jordan D Dimitrakoff — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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