The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose

Completed · Phase 4 · Has a placebo group

Conditions studied: Hypertension

In brief

This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hypertensive patients.

Key facts

Study ID

NCT00673790

Run by

Forest Laboratories

People needed

537

Starts

2008-05-15

Expected to finish

2010-07-09

Last updated by the study team

2020-02-26

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, ambulatory outpatients 18-80 years old at screening.
• Have a history of hypertension and taking up to 2 medications for high blood pressure.
• Qualifying laboratory results confirming impaired fasting glucose or impaired glucose tolerance
• Vision and hearing (hearing aid permissible) sufficient for compliance with questionnaire completion

You may not qualify if…

• Have clinically significant respiratory, liver or cardiovascular disease
• Presence of coronary artery disease requiring treatment with a beat blocker, calcium channel blocker or nitrates
• Use of niacin or antidiabetic drugs (oral or injectable) within 6 months before study entry
• Have a history of hypersensitivity to nebivolol, other beta-blockers, hydrochlorothiazide, or other sulfonamide-derived drugs.

Where it is running

• Forest Investigative Site 101 — Birmingham, Alabama, United States
• Forest Investigative Site 016 — Huntsville, Alabama, United States
• Forest Investigative Site 119 — Phoenix, Arizona, United States
• Forest Investigative Site 078 — Tucson, Arizona, United States
• Forest Investigative Site 056 — Anaheim, California, United States
• Forest Investigative Site 097 — Bell Gardens, California, United States
• Forest Investigative Site 026 — Buena Park, California, United States
• Forest Investigative Site 147 — Buena Park, California, United States
• Forest Investigative Site 061 — Chino, California, United States
• Forest Investigative Site 108 — Costa Mesa, California, United States
• Forest Investigative Site 054 — Encinitas, California, United States
• Forest Investigative Site 128 — Fresno, California, United States
• Forest Investigative Site 127 — Huntington Park, California, United States
• Forest Investigative Site 030 — Long Beach, California, United States
• Forest Investigative Site 085 — Los Angeles, California, United States
• Forest Investigative Site 028 — Los Angeles, California, United States
• Forest Investigative Site 124 — National City, California, United States
• Forest Investigative Site 117 — Riverside, California, United States
• Forest Investigative Site 025 — Roseville, California, United States
• Forest Investigative Site 017 — Sacramento, California, United States
• Forest Investigative Site 068 — San Diego, California, United States
• Forest Investigative Site 112 — Santa Ana, California, United States
• Forest Investigative Site 063 — Temecula, California, United States
• Forest Investigative Site 013 — Tustin, California, United States
• Forest Investigative Site 058 — Athens, Alabama, United States

Full record on ClinicalTrials.gov

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