Corticosteroid Therapy on Glucose Control in Pregnant Women With Diabetes
Completed
Conditions studied: Pregnant Women
In brief
Preterm birth occurs in 25% of women with insulin requiring diabetes in pregnancy. The administration of corticosteroid therapy to accelerate fetal lung maturation is indicated in women at risk for preterm birth. The purpose of this study is to compare the timing, duration and severity of maternal hyperglycemia after corticosteroid administration in women with insulin-requiring diabetes compared to those without diabetes in pregnancy. This is a prospective, observational study. Hourly glucose levels will be obtained for a total of 7 days after corticosteroid administration using the Dexcom Seven continuous glucose monitoring system. In addition, hemoglobin A1C will be obtained to assess the overall level of glycemic control of the participant prior to the corticosteroid therapy.
Key facts
- Study ID
- NCT00673543
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 16
- Starts
- 2008-05-01
- Expected to finish
- 2010-09-01
- Last updated by the study team
- 2017-05-11
Who can join
Age: 18 and older, up to 52. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- The study group will include pregnant women > 18 years of age with insulin-requiring diabetes who will receive corticosteroid therapy to accelerate fetal lung maturation between 24 and 34 weeks of pregnancy. Only those women not in active labor and with singleton gestations will be included. A control group will be comprised of pregnant women with singleton gestations without insulin-requiring diabetes who will receive corticosteroid therapy also to accelerate fetal lung maturation.
You may not qualify if…
- Women will be excluded if they have diet controlled diabetes, twins or higher gestation, are in active labor and anticipate imminent delivery, were previously on any form of steroid therapy, or who have or will be receiving beta-adrenergic medications.
Where it is running
- Lyndon B. Johnson Hospital — Houston, Texas, United States
- Memorial Hermann Hospital Texas Medical Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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