The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils

Status unconfirmed · Phase 4 · Has a placebo group

Conditions studied: Allergy

In brief

If you are allergic to ragweed, and not taking certain medications, you will be asked to have blood drawn. We will perform experiments on your blood cells.

Key facts

Study ID

NCT00673218

Run by

Creighton University

People needed

25

Starts

2007-06-01

Expected to finish

2012-11-01

Last updated by the study team

2012-07-06

Who can join

Age: 19 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 19 to 50
• At least 2 year history of ragweed allergic rhinitis
• Positive skin prick tests to ragweed >5 mm wheal diameter
• IgE <700 iU/m

You may not qualify if…

• Use of prohibited medications (e.g. antihistamine in past 7 days and topical or oral corticosteroids in past 1 month, beta-agonist or theophylline for 2 days.
• History of immunotherapy in the past 2 years
• Exposure to Omalizumab in the past 2 years
• Clinically significant non-allergic or perennial rhinitis to avoid mediator release due to environmental allergens
• Asthma other than mild intermittent
• Women of childbearing potential who are not on an accepted form of birth control, as well as women who are breastfeeding
• Known sensitivity to study drug Xolair
• Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study
• Patients with a previous history of cancer
• Use of any other investigational agent in the last 30 days

Where it is running

• Creighton University — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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