The Effect of Nebivolol in Hypertensive Patients With Coronary Artery Disease

Completed · Phase 4

Conditions studied: Hypertension, Coronary Artery Disease

In brief

This study is being done to see if the blood pressure lowering effect of an approved drug nebivolol is comparable to that of another approved drug carvedilol for the treatment of hypertension in patients who have coronary artery disease.

Key facts

Study ID

NCT00673075

Run by

Forest Laboratories

People needed

39

Starts

2008-05-01

Last updated by the study team

2010-09-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female ambulatory outpatients 18 to 85 of age at screening
• Coronary artery disease as defined by: status post myocardial infarction (heart attack) greater than 14 days post event with no upper time limit (and followed by stress testing with additional imaging (echocardiographic or nuclear) within the 12 months prior to enrollment) and/or angiographic evidence of one or more major coronary arteries narrowing of greater than 50% and/or a history of percutaneous or surgical coronary revascularization greater than 4 months after that procedure at the time of enrollment.
• Qualifying blood pressure criteria for study entry and for randomization
• Willing to adhere to exercise stress (treadmill) tests

You may not qualify if…

• Unstable angina within 7 days of screening
• Potential coronary surgical/intervention within the next 6 months
• Have any form of secondary hypertension
• Have a history of hypersensitivity to nebivolol, metoprolol, carvedilol, or any beta blocker

Where it is running

• Forest Investigative Site — Birmingham, Alabama, United States
• Forest Investigative Site — Peoria, Arizona, United States
• Forest Investigative Site — Buena Park, California, United States
• Forest Investigative Site — Los Angeles, California, United States
• Forest Investigative Site — Orange, California, United States
• Forest Investigator Site — Santa Ana, California, United States
• Forest Investigative Site — Guilford, Connecticut, United States
• Forest Investigator Site — Coral Gables, Florida, United States
• Forest Investigative Site — Daytona Beach, Florida, United States
• Forest Investigator Site — Hollywood, Florida, United States
• Forest Investigator Site — New Smyrna Beach, Florida, United States
• Forest Investigative Site — Orlando, Florida, United States
• Forest Investigator Site — Winter Haven, Florida, United States
• Forest Investigative Site — Chicago, Illinois, United States
• Forest Investigator Site — Indianapolis, Indiana, United States
• Forest Investigator Site — Lafayette, Louisiana, United States
• Forest Investigator Site — Auburn, Maine, United States
• Forest Investigative Site — Pittsfield, Massachusetts, United States
• Forest Investigator Site — Worcester, Massachusetts, United States
• Forest Investigative Site — Detroit, Michigan, United States
• Forest Investigative Site — Lansing, Michigan, United States
• Forest Investigator Site — Las Vegas, Nevada, United States
• Forest Investigative Site — Northport, New York, United States
• Forest Investigative Site — The Bronx, New York, United States
• Forest Investigative Site — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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