Role of TLR4 in Environmental Asthma
Completed · Phase 1
Conditions studied: Asthma
In brief
The overall goal of this project is to identify genes that are involved in the development of airflow obstruction and airway inflammation in asthmatics, and to determine whether polymorphisms in these differentially expressed genes predispose individuals to develop asthma. In this project, we hypothesize that polymorphisms of genes expressed by the airway epithelia in asthmatics following specific airway challenges predispose individuals to the development of asthma.
Key facts
- Study ID
- NCT00671892
- Run by
- John Sundy
- People needed
- 855
- Starts
- 2001-09-01
- Expected to finish
- 2008-04-01
- Last updated by the study team
- 2013-07-16
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- vital signs within normal limits
- negative methacholine challenge (non asthmatic)
- normal PFT's, CXR, EKG
- negative allergy skin tests (non atopic)
- never cigarette smoker
- no chronic illness
- no daily meds except contraceptives
- able and willing to sign informed consent
- not an employee working for,or a student under the authority of the PI's
You may not qualify if…
- allergic rhinitis past or present
- chronic illness resulting in altered lung function
- chronic daily medications
- cigarette smoking
- allergy to acetaminophen or albuterol
- pregnant or nursing females
- PFT results below cut off
- Positive allergy skin test
- Abnormal CXR or EKG
- Positive methacholine challenge
- Infection in the previous 2 weeks
- Past or present allergen immunotherapy
- Occupational exposure to hay or grain
- Other medical or psychological conditions which, in the opinion of the PI, may create undue risk to the subject or interfere with the subject's ability to comply with protocol requirements.
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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