Differential Gene Expression in Lung and Peripheral Blood After Inhaled Allergen Challenge
Stopped early · Phase 1
Conditions studied: Atopic Asthma, Healthy
In brief
The purpose of this study is to identify the genes in important airway cells that are specifically expressed following inhalation of house dust mite allergen among study subjects with either allergic asthma or healthy normal phenotypes. This approach is designed to identify novel genes associated with both asthma pathogenesis (differentially expressed in the exposure-response study) and asthma susceptibility (genetically associated with asthma in a linkage/association study) for drug targets.
Key facts
- Study ID
- NCT00671593
- Run by
- John Sundy
- People needed
- 40
- Starts
- 2006-10-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2013-07-16
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Allergic asthmatic, or nonallergic nonasthmatic
- Willing/able to give informed consent \& adhere to visit/protocol schedules.
- Screening visit laboratory, C-Xray, EKG, results within normal limits
- Women of childbearing potential must have a negative serum pregnancy test
- Screening Pulmonary function testing above study criteria parameters
You may not qualify if…
- Systemic corticosteroid administration for asthma within the previous 90days
- Antibiotic administration within the previous 30 days.
- Viral respiratory infection within the previous 14 days.
- Allergen immunotherapy to House dust mite within the last 10 years
- History of severe asthma requiring intubation.
- Occupational exposure to hay or grain dust.
- Significant exposure history to cigarette smoke
- Past or present history of allergen immunotherapy to within the last 10 yrs
- Underlying illnesses that may result in altered lung function
- Students or employees under direct supervision by protocol investigators are ineligible
- Subjects allergic to medications used (or potentially used) in the study will be excluded.
- Subjects using aspirin will be excluded
- Subjects who abuse alcohol or illicit substances will be excluded
- Medication use other than for asthma, allergies or contraception
- Other medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
- Nursing mothers
- Other investigational medication within the last 30 days
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.