Nitric Oxide, LPS and the Pathogenesis of Asthma Phase 1
Completed
Conditions studied: Healthy, Asthma
In brief
The purpose of the study is to determine the role of nitric oxide (NO) in asthma. We determine the effect of promoter polymorphisms in the gene for the NO producing enzyme, nitric oxide synthase (NOS2), on exhaled NO in healthy African Americans and Caucasians. We compare exhaled NO levels between African Americans and Caucasians. Information on race or ethnicity, serum samples, blood pressure, exhaled breath condensate and health questionnaires will be collected.
Key facts
- Study ID
- NCT00671229
- Run by
- National Institute of Environmental Health Sciences (NIEHS)
- People needed
- 420
- Starts
- 2003-05-01
- Expected to finish
- 2008-06-01
- Last updated by the study team
- 2015-04-14
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willing/able to give informed consent
- self declared non-atopic, non-asthmatic
- never cigarette smoker,
- no significant occupational exposure to respiratory irritants or toxins,
- no chronic illness
- no chronic use of medications (excluding contraceptive medication),
- no historical unstable cardiac or severe lung disease,
- within study age parameters of 18 - 40
You may not qualify if…
- occupational exposure to hay or grain
- smoked 20 or more packs of cigarettes in a lifetime.
- prior allergen immunotherapy
- Allergy and or asthma
- Students or employees under direct supervision by protocol investigators are ineligible
- Nursing mothers
- pregnancy
- Other investigational medication within the last 30 days
- Other medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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