Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome

Completed · Not applicable

Conditions studied: Polycystic Ovary Syndrome

In brief

The purpose of this study is to evaluate the effects of insulin resistance on brain function in women with Polycystic Ovary Syndrome (PCOS). PCOS affected women will be evaluated prior to and following 4-month treatment with Metformin. Additionally, brain function in women with PCOS will be compared to the brain activity in normal control subjects with regular menstrual cycles.

Key facts

Study ID

NCT00670800

Run by

University of Michigan

People needed

14

Starts

2008-01-01

Expected to finish

2009-08-01

Last updated by the study team

2014-05-21

Who can join

Age: 21 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Insulin-resistant PCOS (Arm: PCOS Affected Women)
• Irregular menstrual cycle (Arm: PCOS Affected Women)
• Hyperandrogenism (Arm: PCOS Affected Women)
• Regular menstrual cycles (Arm: Normal Controls)
• Normal hormonal levels (Arm: Normal Controls)
• Lack of hirsutism (Arm: Normal Controls)
• Acne-free (Arm: Normal Controls)
• Candidates are BMI-matched and screened for insulin resistance prior to inclusion. (Arm: Normal Controls)

You may not qualify if…

• Left handedness
• Acute medical illness
• Uncorrected thyroid disease
• Diabetes renal
• Cardiac or pulmonary insufficiency
• Active liver disease
• Neurological disease
• Current psychiatric illness
• Claustrophobia
• Contraindications to MRI
• Smoking
• Use of hormones
• Centrally acting or insulin sensitizing mediations
• Allergy to any opioid medication
• Substance abuse
• Pregnancy
• BMI >35.

Where it is running

• University of Michigan, Michigan Clinical Research Unit — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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