Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa

Completed

Conditions studied: Eating Disorders

In brief

This study will use positron emission tomography imaging to investigate changes in dopamine systems in people with anorexia nervosa before and after weight restoration.

Key facts

Study ID

NCT00670293

Run by

New York State Psychiatric Institute

People needed

50

Starts

2008-07-01

Expected to finish

2015-12-01

Last updated by the study team

2016-04-07

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants with AN:
• Meets DSM-IV criteria for AN or ED-NOS (meets criteria for AN except amenorrhea)
• Sufficiently medically and psychiatrically stable to leave inpatient unit, as assessed by clinical team
• Healthy control participants:
• No current or past psychiatric illness
• Between 80% and 120% of ideal body weight

You may not qualify if…

• All participants:
• Current use of psychotropic medication such as antipsychotics or antidepressants
• Pregnant or breastfeeding
• History of a substance use disorder
• Significant medical illness
• High blood pressure (resting systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg)
• Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV-TR
• Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
• Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
• Previous adverse reaction to psychostimulants

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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