Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Carotid Stenosis

In brief

To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.

Key facts

Study ID

NCT00670202

Run by

Brigham and Women's Hospital

People needed

2

Starts

2008-03-13

Expected to finish

2011-01-20

Last updated by the study team

2017-03-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with >= 70% carotid stenosis (unilateral or bilateral) who are scheduled to undergo elective carotid endarterectomy
• Age >= 18 years
• Agreement of the operating surgeon for patient to participate

You may not qualify if…

• Surgery scheduled < 14 days after randomization
• Pregnancy
• ALT, GGT > 3x upper limit of normal (ULN)
• Creatinine > 3.5 mg/dL
• Prior intolerance to statins
• Reluctance to add or change dosage of statin therapy during study

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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