Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure
Completed · Not applicable
Conditions studied: Acute Liver Failure, Intracranial Hypertension
In brief
Treatment options in patients with high intracranial pressure due to acute liver failure are limited. This study intends to evaluate the effect of prophylactic hypothermia on preventing high intracranial pressure and compromised cerebral oxidative metabolism.
Key facts
- Study ID
- NCT00670124
- Run by
- Rigshospitalet, Denmark
- People needed
- 50
- Starts
- 2005-01-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2014-11-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- acute liver failure
- and hepatic encephalopathy stage 3 or 4
- and informed and written consent by closest relative(s)
- and arterial ammonia concentration above 150 micromol/L or clinical suspicion of cerebral edema
- and an ICP-measuring device
You may not qualify if…
- no or withdrawn informed consent
- pregnant or breast feeding women
- uncontrollable infection
- hemodynamically instable patients
- active bleeding
Where it is running
- Division of Hepatology, Feinberg School of Medicine, Northwestern University — Chicago, Illinois, United States
- Department of hepatology, Rigshospitalet — Copenhagen, Denmark
- Dept. of Intensive Care — Birmingham, United Kingdom
- Institute for Liver Studies, King's College Hospital — London, United Kingdom
Full record on ClinicalTrials.gov
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