T-wave Alternans and Intrathoracic Impedance Measurements
Completed
Conditions studied: Congestive Heart Failure, Arrhythmias
In brief
T-wave alternans is a test that is currently being used to risk stratify patients with structural heart disease for sudden cardiac death. The mechanism of T-wave alternans is unclear, but may share a common abnormality with conditions of cardiac fluid overload such as heart failure, which is altered intracellular calcium handling. Current Medtronic implantable defibrillators have the capability of monitoring cardiac fluid status via transthoracic impedance measurements. The purpose of this study is to determine if a correlation exists between T-wave alternans status and cardiac volume status, as determined by transthoracic impedance measurements. Secondarily, the study seeks to examine the relationship between arrhythmia frequency and T-wave alternans or cardiac volume status.
Key facts
- Study ID
- NCT00669682
- Run by
- Columbia University
- People needed
- 9
- Starts
- 2008-08-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2013-04-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Class III or IV heart failure patients with a chronically implanted Medtronic biventricular defibrillator system capable of monitoring intrathoracic fluid volume.
You may not qualify if…
- no active ischemia or pulmonary edema, atrial fibrillation, complete heart block
Where it is running
- Columbia University Medical Center — New York, New York, United States
Full record on ClinicalTrials.gov
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