Rescue Antenatal Steroids and Pulmonary Function Tests in Preterm Infants
Completed · Not applicable · Has a placebo group
Conditions studied: Respiratory Compliance, Functional Residual Capacity, Pulmonary Function Testing
In brief
One course of steroids given to a mother before a premature delivery helps the lungs of the premature infant and decreases breathing problems. One course of antenatal steroids is the standard of care for threatened premature deliveries. It is unclear as to how long the benefit of one course of steroids last. The most benefit to the baby's lungs seem to occur if the steroids are given at least 24 hours before but within 7 days of a premature delivery. It is difficult to predict the timing of a preterm delivery so deliveries often do not occur within this time period. We hypothesize that the benefits of the steroids to the lungs wear off if the steroids are given more than 14 days before a preterm delivery, and that in these circumstances an extra course of steroids will help the premature baby's lungs and the premature baby will have less breathing problems as shown by lung function testing.
Key facts
- Study ID
- NCT00669383
- Run by
- Oregon Health and Science University
- People needed
- 85
- Starts
- 2001-06-01
- Expected to finish
- 2009-11-01
- Last updated by the study team
- 2019-02-22
Who can join
Age: 15 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Greater than 14 days after first course of antenatal steroids;
- Less than 34 weeks of gestation;
- Identified by primary physician as continued risk for preterm delivery;
- Informed consent
You may not qualify if…
- Major congenital anomalies
- Multiple gestation of triplets or greater
- Mother with insulin dependent diabetes
Where it is running
- Oregon Health & Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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