Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Alzheimer Disease

In brief

This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab or placebo. Each patient's participation will last approximately 1.5 years.

Key facts

Study ID

NCT00667810

Run by

Pfizer

People needed

901

Starts

2008-06-01

Expected to finish

2013-08-01

Last updated by the study team

2016-01-08

Who can join

Age: 50 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable Alzheimer Disease (AD), with Mini Mental State Examination (MMSE) score of 16-26, and brain magnetic resonance imaging (MRI) consistent with the diagnosis of AD
• Concurrent use of cholinesterase inhibitor or memantine allowed, if stable
• Caregiver will participate and be able to attend clinic visits with patient

You may not qualify if…

• Significant neurological disease other than AD
• Major psychiatric disorder
• Contraindication to undergo brain MRI [e.g., pacemaker, cerebrospinal fluid (CSF) shunt, or foreign metal objects in the body]
• Women of childbearing potential

Where it is running

• Dedicated Clinical Research — Goodyear, Arizona, United States
• Banner Alzheimer's Institute — Phoenix, Arizona, United States
• Jeffrey S. Gitt, DO, PC — Phoenix, Arizona, United States
• The Compounding Center (IP Mixing Only) — Phoenix, Arizona, United States
• Hope Research Institute — Phoenix, Arizona, United States
• Clinical Trials, Inc. — Little Rock, Arkansas, United States
• ATP Clinical Research, Incorporated — Costa Mesa, California, United States
• Pharmacology Research Institute — Encino, California, United States
• Margolin Brain Institute — Fresno, California, United States
• Infusion Care Pharmacey — Laguna Hills, California, United States
• Senior Clinical Trials, Incorporated — Laguna Hills, California, United States
• Faculty Physicians and Surgeons of Loma Linda University School of Medicine — Loma Linda, California, United States
• Loma Linda University Medical Center — Loma Linda, California, United States
• Collaborative Neuroscience Network, Inc. — Long Beach, California, United States
• Pharmacology Research Institute — Los Alamitos, California, United States
• Pharmacology Research Institute — Newport Beach, California, United States
• Coordinated Clinical Research — San Diego, California, United States
• LabCorp — San Diego, California, United States
• Sharp and Children's MRI Center, LLC — San Diego, California, United States
• Sharp Infusion Therapy Center — San Diego, California, United States
• Sharp Memorial Hospital — San Diego, California, United States
• Sharp Mesa Vista Hospital — San Diego, California, United States
• San Francisco Clinical Research Center — San Francisco, California, United States
• Alpine Clinical Research Center, Inc. — Boulder, Colorado, United States
• University of Alabama-Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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