Aging, Lifestyle and Inflammation in Veterans Exercising
Completed · Not applicable
Conditions studied: Inflammation, Aging, Metabolism, Exercise
In brief
Over half of adults in this country are overweight. This increases risk for heart and blood pressure problems, cancer, stroke and arthritis. While it is difficult to lose large amounts of weight and keep it off, even small amounts of weight loss can improve health. Furthermore, fat is increasingly recognized as a source of substances that increase inflammation. It may be that some of the adverse consequences of being overweight are due to increased inflammation. We are asking you to volunteer for a research study in which you may lose a moderate amount of weight and increase your activity. It is important that you read and understand the information on this form. The purposes of these studies are to determine the influence(s) of age and body composition on the production of inflammatory chemicals by fat (adipose tissue), the mechanisms controlling this, and if a weight loss and aerobic exercise intervention results in a decrease in inflammation.
Key facts
- Study ID
- NCT00667030
- Run by
- University of Maryland, Baltimore
- People needed
- 100
- Starts
- 2005-07-01
- Expected to finish
- 2018-09-13
- Last updated by the study team
- 2026-02-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BMI 20-40 kg/m2
- Waist 80-120cm (men), 70-110cm (women)
- Stable Medical Regimen > or = 30 days
- All women over the age of 50 must be postmenopausal for at least 1 year, have serum FSH >30 mIU/ml, and agree to remain off hormone replacement therapy for the duration of the study
You may not qualify if…
- Pregnancy or Nursing Mothers
- Cigarette Smoking
- Diabetes on Medication or Fasting Glucose >126 mg/dl
- Poorly controlled hypertension requiring >3 drugs or beta blockers
- Hyperlipidemia with TG>400mg/dl, LDL>190mg/dl or on Lipitor or Crestor
- Other medications affecting glucose, lipid or cytokine levels
- Thyroid Disease
- Weight gain/loss >5kg in preceding 3 months
- Alcohol >3oz/day
- Caffeine >120 oz/day
- Chronic liver, renal or hematological disease
- Lung disease requiring oxygen
- Active cancer on radiation or chemotherapy treatment
- HIV (+) or other disease prone to malnutrition
- Sickle cell anemia
- Active psychosis or dementia
- Chronic untreated depression
- Hemiparetic Stroke
- Coronary Artery or cerebrovascular disease precluding exercise
- Implantable defibrillator
- Other medical condition precluding exercise testing or participation in exercise and weight loss programs, as per medical judgement of study team
Where it is running
- University of Maryland; Baltimore VA Medical Center — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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