Research Tissue Bank

Completed

Conditions studied: Myelofibrosis, Idiopathic Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera

In brief

This study that will allow for the preservation and/or storage of a small portion one or more of the following tissues: * Peripheral blood * Bone marrow * Bone marrow biopsy * A phlebotomized unit of blood * Spleen cells * Toenail clippings This material will be used for the study of Myeloproliferative Disorders (MPD) by researchers. The goals of this research study are to understand the causes of MPDs, how to diagnose them more easily and how to treat them better. MPD is a disease affecting hematopoietic stem cells. Hematopoietic stem cells are cells that make blood cells. These stem cells grow in the center portion of the bones called bone marrow. Under some conditions, these cells are also found in blood. There are several diseases, which are classified as MPD. These include polycythemia vera (too many red blood cells), essential thrombocythemia (too many platelets), and idiopathic myelofibrosis (abnormal blood cells and fibers build up in the bone marrow). These syndromes carry a high risk of developing leukemia. It is important to continue to learn more about these blood cancers and to learn more about the effectiveness and potential side effects of various treatments.

Key facts

Study ID

NCT00666549

Run by

Icahn School of Medicine at Mount Sinai

People needed

963

Starts

2007-09-01

Expected to finish

2017-03-27

Last updated by the study team

2019-07-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients diagnosed with Philadelphia chromosome negative myeloproliferative disorders (MPD) polycythemia vera (PV), idiopathic myelofibrosis (IM), and essential thrombocythemia (ET) are eligible.
• Newly diagnose MPD patients as well as previously treated for a MPD are eligible.
• Signed informed consent is required from each patient at the time of enrollment.

You may not qualify if…

• Patients currently participating in experimental treatment arms of MPD-RC protocols, or other experimental treatment protocols are not eligible during the period they are on study.

Where it is running

• Palo Alto Medical Foundation Research Institute — Palo Alto, California, United States
• Weill Cornell University — Washington D.C., District of Columbia, United States
• University of Georgetown — Washington D.C., District of Columbia, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Johns Hopkins — Baltimore, Maryland, United States
• Roswell Park — Buffalo, New York, United States
• Mount Sinai Medical Center — New York, New York, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States
• Ospedali Riuniti di Bergamo — Bergamo, IL, Italy
• University of Florence — Florence, IL, Italy

Full record on ClinicalTrials.gov

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