Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotypes

Completed

Conditions studied: Schizophrenia, Bipolar

In brief

Briefly, this multisite study is designed to identify endophenotypes (i.e., heritable biomarkers) associated with either schizophrenia or bipolar disorder alone, or both together. The subsequent genetic analyses will search genomic loci and candidate genes associated with each of the independent endophenotypes. This is a five site study that is slotted for NIMH funding.

Key facts

Study ID

NCT00666432

Run by

University of Maryland, Baltimore

People needed

3500

Starts

2008-05-01

Expected to finish

2019-11-22

Last updated by the study team

2021-05-03

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female participants 15 years of age and above.
• Case probands will include individuals who meet DSM-IV criteria for schizophrenia, schizoaffective, or bipolar disorder with psychosis

You may not qualify if…

• Control subjects who meet DSM-IV criteria for any lifetime psychotic illness or BP, or have a family history of psychotic or BP disorders in their first or second-degree relatives will be excluded.
• A number of exclusions are necessary because they potentially affect neurophysiological measures. Exclusions will be applied to all groups to maintain consistency in recruitment. As a result, the following individuals will be excluded:
• Subjects under 15 years of age will be excluded. Subjects with serious medical, neuro-ophthalmological or neurological illness (e.g., cancer, seizure disorders, encephalopathy) will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
• Subjects with current substance abuse (within 6 months), dependence within 2 years or extensive history of drug dependence will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
• Subjects with mental retardation will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
• Subjects with ferromagnetic objects lodged in body will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
• Schizophrenic patients who are judged to be incompetent to provide voluntary informed consent based on the ESC evaluation.
• Any participant who would require an x-ray to rule out the presence of metal in their body prior to an MRI scan

Where it is running

• Hartford Hospital- The Institute of Living — Hartford, Connecticut, United States
• Center for Cognitive Medicine — Chicago, Illinois, United States
• Johns Hopkins School of Medicine — Baltimore, Maryland, United States
• University of Maryland, Baltimore — Baltimore, Maryland, United States
• Wayne State University School of Medicine — Detroit, Michigan, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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