Sex, Aging and Antiretroviral Pharmacokinetics

Completed

Conditions studied: HIV Infections

In brief

The purpose of this research study is to learn about levels of antiretroviral drug levels and response to HIV virus in the genital tract of women who are post-menopausal. The investigators in this study think that the levels of hormones post-menopausal HIV-infected women may have in their bodies may affect the levels of antiretroviral drug, and therefore affect how much HIV virus they have in their bodies. Since women who have already gone through menopause have different levels of hormones, such as estrogen, than women who are pre-menopausal, the investigators would like to check the levels of antiretroviral drugs in their blood, their genital secretions, and their genital tissue.

Key facts

Study ID

NCT00666055

Run by

Kristine Patterson, MD

People needed

11

Starts

2008-03-01

Expected to finish

2012-05-01

Last updated by the study team

2012-09-20

Who can join

Age: 19 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• HIV-infected women >18 years of age
• There are no specific entry criteria for CD4+ T-cell counts and plasma HIV RNA.
• Menopause status will be determined at screening.
• Post-menopausal will be defined as the cessation of menses for >12 months (or undergone a bilateral oophorectomy with or without a hysterectomy) AND a FSH >25 miu/mL and estradiol level <20 pg/mL establishing both physiological and biochemical evidence of menopause.
• Pre-menopausal women must have regular cycles without peri-menopausal vasomotor symptoms and not receiving exogenous hormones.
• Women may be changing to a new regimen because of virologic failure or intolerability. Women in whom resistance testing is available, two or more drugs to which the virus is susceptible needs to be included in the proposed treatment regimen.
• Women may also be naïve to either NNRTI or PIs and initiating their first, second or third HAART regimen (ARVs to be investigated: zidovudine, lamivudine, emtricitabine, abacavir, tenofovir, efavirenz, lopinavir/ritonavir, atazanavir with or without ritonavir).
• Provided the ARV regimens contain one or more of the agents under study they may also include new agents such as maraviroc (CCR5 inhibitor), raltegravir (integrase inhibitor) and/or etravirine (NNRTI). Samples will be stored so that the pharmacokinetics of these agents can be evaluated in future studies once the assays are available in our lab.
• Women must be free from sexually transmitted infections (STI's) at the time of enrollment.
• Women must be able to abstain from douching and sexual activity for 72 hours prior to all study visits.
• Subjects must be willing to have genital tract samples taken.

You may not qualify if…

• Women currently receiving medication with known drug-drug interaction with the ARVs under study.
• Women currently receiving any exogenous hormone therapy (contraception, estrogen replacement therapy or androgen supplements). Women must be off all exogenous hormone therapy for > 16 weeks prior to enrollment.
• Women who are pregnant or breast-feeding.
• Women with a hemoglobin <9.0g/dL and/or hematocrit <28%.
• Women unable to complete, or have a caretaker complete, a dose administration card.
• Women who, in the judgement of the investigator, are unable to comply with the protocol requirements.
• Women who are unable to give written informed consent.
• Women who cannot comply with abstaining from intercourse or douching 48 hours prior to study examination.
• Male or transgender individuals.

Where it is running

• The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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