Diet, Exercise, Metabolism, and Obesity in Older Women

Completed · Not applicable

Conditions studied: Abdominal Obesity, Metabolic Syndrome

In brief

Reductions in fat oxidation and resting metabolic rate (RMR) are associated with normal aging and are accelerated with menopause. As a result, postmenopausal women have an increased risk of abdominal obesity and ultimately the metabolic complications that lead to the insulin resistance syndrome and its associated risks (hyperlipidemia, type 2 diabetes, and coronary heart disease). Thus, there is a need to determine the most successful treatment to reduce visceral obesity in postmenopausal women. The purpose of this study is to determine if dietary-induced weight loss alone and/or weight loss combined with exercise at low and high- intensities differentially affect the reduction in visceral adipose tissue in postmenopausal women with abdominal obesity.

Key facts

Study ID

NCT00664729

Run by

Wake Forest University Health Sciences

People needed

112

Starts

2002-11-01

Expected to finish

2008-11-01

Last updated by the study team

2018-08-01

Who can join

Age: 50 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Currently 50 - 70 years of age (at screening)
• Post-menopausal at least 1 year
• Waist diameter of at least 34"
• Able to attend exercise classes 3 times per week
• BMI between 25 \& 40 kg/m2
• MMSE > 25

You may not qualify if…

• Exercises regularly (ie- more than twice a week for more than 15 minutes per session)?
• Uncontrolled diabetes mellitus or insulin-controlled diabetes?
• Does not drive and does not have a reliable way to pick up meals once a week
• Cancer in past 5 years except skin cancer
• Unwilling or unable to eat prepared foods (non-compliant during test week)
• Unwilling or unable to record food intake accurately
• Self-reported weight loss or gain >5% in past 6 months
• Smoking within past year, or use of tobacco or nicotine product
• Coronary artery disease, liver disease, renal disease, or other systemic disorders
• Pulmonary disease
• Current use of thiazide diuretics, beta blockers or steroids
• Current use of more than one anti-hypertensive medication
• Current use of anti-depressants or hormone replacement therapy
• Gross physical impairment
• Blindness or retinopathy
• Triglyceride level >400 mg/dl
• Anemia (Hct < 37%)
• Contraindication to exercise by ECG or GXT

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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