Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior

Completed · Not applicable · Has a placebo group

Conditions studied: Cardiovascular Diseases, Mood Disorders, Inflammation

In brief

Omega-3 fatty acids are a certain kind of fish fat that has recently been shown to have health benefits. This study will examine the effectiveness of fish oil supplementation for reducing the early signs of heart disease risk and for improving mood, impulsivity, and anger levels.

Key facts

Study ID

NCT00663871

Run by

University of Pittsburgh

People needed

272

Starts

2008-06-01

Expected to finish

2012-10-01

Last updated by the study team

2021-06-11

Who can join

Age: 30 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Currently employed at least 25 hours a week, but does not regularly work the third shift (i.e., night shift)
• English is primary language
• Consumes less than 300 mg/day of long-chain omega-3 fatty acids.

You may not qualify if…

• Serious allergy to fish (e.g., anaphylaxis, bronchospasm, serious skin reaction)
• History of atherosclerotic disease (e.g., myocardial infarction) or treatment of angina or claudication (e.g., angioplasty)
• Reported history of schizophrenia or bipolar disorder
• Long-term hepatitis
• Kidney failure
• Stroke or other neurological disorder
• Lung disease requiring drug treatment
• Stage 2 high blood pressure, defined as systolic blood pressure of 160 mm Hg or greater and diastolic blood pressure of 100 mm Hg or greater
• Alcohol consumption of more than five drinks per day each week (i.e., more than 35 alcoholic drinks each week)
• Pregnant or breastfeeding
• Currently taking any cardiovascular, psychotropic, glucocorticoid, lipid-lowering, insulin, or weight loss medications
• Currently taking fish oil supplements

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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