Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation

Completed · Not applicable · Has a placebo group

Conditions studied: Constipation

In brief

Patients requiring opioids for post-operative pain control following elective orthopedic procedures which has resulted in constipation symptoms, and who are in inpatient rehabilitation will be randomized to two different treatment arms: lubiprostone or senna. Baseline scores regarding constipation and a quality of life bowel questionnaire will be compared the day following 6 days of treatment intervention.

Key facts

Study ID

NCT00662363

Run by

Shirley Ryan AbilityLab

People needed

64

Starts

2008-04-01

Expected to finish

2011-10-01

Last updated by the study team

2013-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult, 18 years old or greater.
• The patient is able to provide informed consent.
• Anticipated duration of hospitalization of at least 7 days.
• Woman of childbearing potential must have a negative serum pregnancy test at enrollment. Exclusions for testing include two years or greater postmenopausal, hysterectomy or tubal ligation.
• Use of opioid for post-op analgesia following orthopedic surgical procedures as defined as IV, IM, transdermal or PO opioid received within the prior 24 hours of hospitalization for pain control, and expectation that an opioid will be continued for pain control.
• Medication may be administered on a PRN (as needed) basis or scheduled basis
• One or greater doses has been received within the 24 hours prior to enrollment as determined by medication administration recorded from the acute care facility or RIC MAR.
• At least one associated symptom of constipation at the time of admission, such as, but not limited to:
• Lumpy or Hard stools
• Feeling of incomplete evacuation of bowels
• Abdominal cramping or pain
• Straining with movement of bowels or painful bowel movement effort
• Need for manual assistance to have a bowel movement

You may not qualify if…

• Known allergy or sensitivity to the study medications
• Females who are pregnant
• Diarrhea on the day of admission
• Diagnosis of Clostridium difficile infection during the current hospitalization
• Pre-existing medical condition or surgical procedure, which is known to commonly lead to bowel dysfunction such as, but not limited to:
• Crohn's disease
• Ulcerative colitis
• Multiple sclerosis
• Cerebral palsy
• Spinal Cord Injury
• Colectomy
• Malabsorption Syndrome
• Irritable Bowel Syndrome
• Abdominopelvic neoplasm (gastric, colon cancer)
• Severe liver disease
• Colonic or ileo-colonic resections

Where it is running

• Rehabilitation Institute of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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