Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure of Sequential Endocrine Therapy
Stopped early · Phase 2
Conditions studied: Breast Cancer, Cancer of the Breast, Neoplasms, Breast
In brief
This trial seeks to confirm the response rate for estrace treatment in a patients with hormone receptor positive metastatic breast cancer heavily pre-treated with modern endocrine therapies.
Key facts
- Study ID
- NCT00661531
- Run by
- Georgetown University
- People needed
- 11
- Starts
- 2008-04-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2017-04-12
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed estrogen and/or progesterone receptor-positive breast cancer metastatic breast cancer
- Clinically determined evaluable disease
- Post-menopausal woman
- Previous clinical benefit from prior anti-estrogen therapies and subsequent failure of at least 2 prior endocrine therapies.
- May have had chemotherapy for adjuvant \&/or metastatic disease.
- May have had radiation therapy but not to the only site of disease.
- Ecog performance status </= 2.
- Life expectancy of > 6 months
You may not qualify if…
- Chemotherapy or radiotherapy within 1 week of beginning treatment in the clinical trial
- Brain metastasis
- Prior history of or active thrombophlebitis, deep venous thrombosis or pulmonary embolus
- Current vaginal bleeding
- Hypercalcemia or hypocalcemia
- History of or active hepatic adenoma
- No other malignancies within the past 5 years with the exception of curatively treated basal cell or squamous cell carcinoma of the skin or carcinoma in-situ of the cervix
Where it is running
- Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Cooper Cancer Institute — Voorhees Township, New Jersey, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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