Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940

Completed · Phase 2 · Has a placebo group

Conditions studied: Pain

In brief

The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1940 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller naproxen for comparison purposes. Rescue medication, acetaminophen, will be allowed if a need for additional painkillers would arise. A number of patients will receive Naproxen as control.

Key facts

Study ID

NCT00659490

Run by

AstraZeneca

People needed

151

Starts

2008-02-01

Expected to finish

2008-05-01

Last updated by the study team

2012-06-11

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients scheduled for surgical removal of one partial or complete impacted mandibular third molar.
• Provision of signed informed consent.
• Healthy males or non-fertile females.

You may not qualify if…

• History of somatic disease/condition, which may interfere with the objectives of the study, as judged by the investigator.
• History of previous or ongoing psychiatric disease/condition including psychosis, affective disorder, anxiety disorder, borderline state and personality disorder according to the criteria in the Diagnostic and Statistical Manual of Mental Disorder, 4th edition.

Where it is running

• Research Site — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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