Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults

Completed · Phase 2 · Has a placebo group

Conditions studied: Cannabis Dependence, Cannabis Withdrawal

In brief

The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using cannabis. An additional goal is to characterize the severity of cannabis dependence using precipitated and naturalistic withdrawal with a double blind, placebo controlled, single administration of rimonabant. Research assessments occur bi-weekly throughout this 28 day study.

Key facts

Study ID

NCT00656487

Run by

The Scripps Research Institute

People needed

66

Starts

2008-04-30

Expected to finish

2011-01-06

Last updated by the study team

2017-06-19

Who can join

Age: 21 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• males or females 21-30 years of age
• meets Diagnostic and Statistical Manual (DSM-IV) diagnosis of Cannabis Dependence
• willing to be abstinent for 28 days during study
• smokes < 10 cigarettes per day
• drinks < 1 (female) or < 2 (male) per day

You may not qualify if…

• active suicide ideation
• meets DSM-IV diagnosis for dependence on other substances other than cannabis
• significant medical disorders
• pregnant women
• meets DSM-IV diagnosis for a major Axis I disorder other than cannabis dependence
• currently taking psychoactive medication

Where it is running

• The Scripps Research Institute — La Jolla, California, United States

Full record on ClinicalTrials.gov

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