Phase 1 Study of MKC-1 in Patients With Advanced Cancer

Completed · Phase 1

Conditions studied: Advanced Cancer

In brief

This is an open-label study to determine the highest dose of MKC-1 that may be administered daily on a continuous basis for patients with advanced or refractory solid tumors.

Key facts

Study ID

NCT00656461

Run by

CASI pharmaceuticals, Inc.

People needed

24

Starts

2008-03-01

Expected to finish

2009-11-01

Last updated by the study team

2009-11-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have histologically confirmed malignancy that is metastatic or unresectable and for which standard curative measures do not exist or are no longer effective.
• Age greater than or equal to 18 years.
• ECOG performance status ≤1
• ANC greater than or equal to 1,500/mm3;
• Platelets greater than or equal to 100,000/mm3
• creatinine ≤1.5 times institutional upper limit of normal (ULN)
• T Bili within normal limits;
• AST and ALT less than or equal to 2.5 times ULN; and
• albumin greater than or equal to 3.0 g/dL
• have measurable disease by RECIST, radiographically evaluable disease, or detectable disease
• women of child-bearing potential and men must agree to use adequate contraception
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Have previously received MKC-1.
• Have received radiation to greater than 25% of the bone marrow.
• Have had anti-cancer therapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
• Are concurrently receiving any other investigational agents while on study.
• Have known brain metastases
• Have any condition that impairs the ability to swallow and retain MKC-1 capsules.
• Uncontrolled intercurrent illness
• Are pregnant or breastfeeding
• HIV-positive patients
• Patients with uncontrolled diabetes

Where it is running

• U. of Wisconsin Paul P. Carbone Comprehensive Cancer Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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