Corticosteroid Injection as a Predictor of Outcome in Carpal Tunnel Release

Stopped early

Conditions studied: Carpal Tunnel Syndrome

In brief

This study will investigate whether symptomatic improvement following carpal tunnel corticosteroid injection can be correlated to symptomatic improvement following carpal tunnel release and therefore serve as a prognostic indicator. Clinical question: Does response to corticosteroid injection in CTS predict outcomes of surgical treatment? Secondary Questions: 1. Can we confirm previous retrospectively collected data that a certain percentage of conservatively managed patients with steroid injection will avoid surgery, and that patients who undergo surgery will have better outcomes than those who do not. 2. Are there differences between worker's compensation and non-worker's compensation patients with regard to the primary clinical question? 3. What are Carpal Tunnel Release outcomes for the subset of patients with negative electrophysiologic studies? 4. What are the outcomes of patients who undergo carpal tunnel release vs. those who choose not to undergo carpal tunnel release? A prospective cohort design study is the appropriate study design in order to measure the association between a predictor (response to injection) and outcome (response to surgery).

Key facts

Study ID

NCT00655915

Run by

Vanderbilt University

People needed

200

Starts

2007-12-01

Expected to finish

2011-03-01

Last updated by the study team

2011-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a clinical diagnosis of carpal tunnel syndrome
• English speaking patients only

You may not qualify if…

• Patients less than 18 years old
• Patients who are pregnant by patient report or intending to become pregnant during the study
• Patients unwilling or unable to return for follow-up visits prescribed by the study protocol.
• Patients who qualify for inclusion in the study, but refuse to participate.
• Patients with evidence of thenar atrophy on exam
• Patients with a diagnosis of peripheral neuropathy or other neuropathy.
• Patients with previous ipsilateral carpal tunnel injection or release.

Where it is running

• Vanderbilt Hand & Upper Extremity Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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