Effect of Timi3 Ultrasound on Myocardial Blow Flow in the Hibernating Myocardium

Stopped early · Early Phase 1

Conditions studied: Myocardial Ischemia

In brief

The purpose of this study is to evaluate whether the use application of low frequency ultrasound, administered by the Timi3 ultrasound device, increases myocardial blood flow to the heart, in subjects with reduced myocardial blood flow at rest (hibernating myocardium). The primary endpoint of the trial is to assess the increase in myocardial blood flow from baseline to post Timi3 Ultrasound treatment in a hypoperfused region of myocardium. Positron emission tomography (PET) imaging will be used to noninvasively evaluate cardiac blood flow. The hypothesis is that ultrasound increases blood flow in hibernating myocardium.

Key facts

Study ID

NCT00655070

Run by

University of California, San Francisco

People needed

9

Starts

2008-04-01

Expected to finish

2010-12-01

Last updated by the study team

2012-04-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >/= 18 years
• Must have reversible resting ischemia, resting non-reversible blood flow defect, or stress-induced ischemia.
• Females with childbearing potential must not be pregnant at the time of the study
• Must provide written informed consent

You may not qualify if…

• Unable or unwilling to cooperate with study procedures
• Currently enrolled in another clinical study for which the follow-up period is not complete

Where it is running

• UC San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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