Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression

Completed · Phase 2/Phase 3

Conditions studied: Depression

In brief

This study will examine changes in brain dopamine transporter activity before and after antidepressant therapy.

Key facts

Study ID

NCT00655057

Run by

University of Pennsylvania

People needed

66

Starts

2005-10-01

Expected to finish

2009-12-01

Last updated by the study team

2020-04-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• DSM-IV diagnosis of major depressive episode (MDE) or major depressive disorder (MDD)
• Drug free of psychotropic medication for more than 6 months before study entry
• 17-item Hamilton Depression Scale (HAM-D17) score of greater than 16
• Woman of childbearing age with a negative pregnancy test within 48 hours of study entry
• Absence of DSM-IV Axis I diagnosis as determined by Structured Clinical Interview for DSM Disorders (SCID)

You may not qualify if…

• DSM-IV Axis I diagnosis other than MDE
• History of mania
• Current alcohol or drug abuse, or alcohol or drug dependence within 6 months before study entry
• History of sensitivity or intolerance to s-citalopram
• Medical contraindication to the use of s-citalopram
• Unstable medical condition (e.g., angina pectoris, untreated hypertension)
• Pregnant or breastfeeding
• Woman of childbearing potential not using a medically acceptable form of birth control
• Actively suicidal or requiring hospitalization
• Requiring additional psychotropic drug therapy
• History of transient ischemic attacks
• History of cerebral infarction (including lacunar infarct with symptoms that last more than 24 hours)
• History of Binswanger's disease (or a history of hypertensive encephalopathy)
• History of intracranial hemorrhage
• History of head trauma with loss of consciousness
• History of encephalitis
• History of extended exposure to known neurotoxin (e.g., cyanide, carbon monoxide)
• Uncontrolled metabolic disorder (e.g., thyroid disease, diabetes mellitus)
• History of cognitive impairment other than MDE
• History of normal pressure hydrocephalus
• History of cancer metastatic to the central nervous system
• History of Parkinson's disease or other basal ganglia disease
• History of Guillain-Barre syndrome (chronic or relapsing polyneuropathy)
• Inability to undergo an MRI scan
• History of DSM-IV Axis I Mood Disorder

Where it is running

• Depression Research Unit - University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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