Inhalation of 20,000 Endotoxin Units(EU) of Clinical Center Reference Endotoxin in Healthy Volunteers

Completed · Phase 1

Conditions studied: Healthy Adults

In brief

The purpose of this study is to determine the inflammatory response to 20,000 endotoxin units (EU) of CCRE (Clinical Center Reference Endotoxin) inhalation in a cohort of healthy volunteers. Preferably these subjects will have participated in ozone exposure studies, allowing a direct comparison of their responses to both endotoxin and ozone. Additionally, cardiovascular endpoints will be investigated with the CCRE exposure.

Key facts

Study ID

NCT00654134

Run by

University of North Carolina, Chapel Hill

People needed

20

Starts

2005-10-01

Expected to finish

2013-07-01

Last updated by the study team

2013-08-09

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Prior participation in Ozone Study
• Healthy adults
• Nonsmokers
• No chronic illness
• No active allergies

You may not qualify if…

• Reduced Lung function
• Asthma

Where it is running

• Us Epa Hsf — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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