Bridging Therapy in Patients at High Risk for Stent Thrombosis Undergoing Surgery
Status unconfirmed
Conditions studied: Bleeding, Thrombosis
In brief
Patients who have undergone placement of coronary stents require dual antiplatelet therapy with Plavix and aspirin to prevent the serious complication of in-stent thrombosis. Some of these patients will require surgery while on dual antiplatelet therapy. This poses a challenge because being on Plavix is associated with higher risks of perioperative bleeding, but stopping Plavix puts patients at increased risk for in-stent thrombosis. Currently, the ACC/AHA guidelines recommend discontinuation of Plavix five days prior to surgery to prevent bleeding complications. However, there are no universal recommendations for preventing in-stent thrombosis. Some experts recommend the use glycoprotein IIb/IIIa inhibitors (short-acting antiplatelet agents) as "bridging therapy" during the high-risk perioperative period. Although these agents should be beneficial based on theory, there is currently no published data on their effectiveness for this purpose. The current study proposes to evaluate the value of Aggrastat (a short-acting intravenous platelet glycoprotein IIb/IIIa inhibitor) in decreasing the risk of in-stent thrombosis without increasing the risk of perioperative bleeding.
Key facts
- Study ID
- NCT00653601
- Run by
- Cedars-Sinai Medical Center
- People needed
- 20
- Starts
- 2008-04-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2009-09-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients' with BMS/DES on plavix prior to surgery who are in need of an elective procedures
You may not qualify if…
- Patients' with BMS/DES on NOT plavix prior to surgery who are in need of an elective procedures
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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