Bone Health in Type 1 Diabetes

Completed

Conditions studied: Type 1 Diabetes, Osteoporosis

In brief

An increased skeletal fracture risk in diabetes has only recently been recognized. This human study is designed to elucidate the effect of Type 1 diabetes on bone remodeling and on structure.

Key facts

Study ID

NCT00651196

Run by

Creighton University

People needed

60

Starts

2008-01-01

Expected to finish

2013-01-01

Last updated by the study team

2013-03-18

Who can join

Age: 19 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 19 yrs or < 50 yrs.
• The diabetic subjects must have a diagnosis of Type 1 diabetes clinically defined as diabetes onset before age 50, acute presentation or diabetic ketoacidosis, with normal BMI. If history is equivocal, GAD antibodies > 1.45 U/mL will be used to define diagnosis.
• Diabetic subjects must be on insulin treatment.
• All subjects must have BMI between 18-30

You may not qualify if…

• On any medications that are known to interfere with bone metabolism including loop diuretics, steroids, anticonvulsants, bisphosphonates, metformin, glitazones
• Have normal or only mildly impaired kidney function defined as a calculated GFR greater than 60 mL/min/1.73m2
• History of cancer other than skin cancer
• Unstable angina, myocardial infarction, uncontrolled hypertension, malabsorption, active rheumatoid or collagen disease.

Where it is running

• Creighton University — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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