Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
Completed · Phase 1
Conditions studied: Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Recurrent Adult Brain Tumor
In brief
This phase I trial is studying the side effects and best dose of aflibercept when given together with radiation therapy and temozolomide in treating patients with newly diagnosed or recurrent glioblastoma multiforme, gliosarcoma, or other malignant glioma. Aflibercept may stop the growth of tumor cells by blocking blood flow to the tumor. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving aflibercept together with radiation therapy and temozolomide may kill more tumor cells.
Key facts
- Study ID
- NCT00650923
- Run by
- National Cancer Institute (NCI)
- People needed
- 61
- Starts
- 2008-07-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-05-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California at Los Angeles (UCLA ) — Los Angeles, California, United States
- UCSF-Mount Zion — San Francisco, California, United States
- University of California San Francisco Medical Center-Parnassus — San Francisco, California, United States
- Adult Brain Tumor Consortium — Baltimore, Maryland, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Massachusetts General Hospital — Charlestown, Massachusetts, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- M D Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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