Anaplerotic Therapy in Propionic Acidemia

Completed · Phase 1

Conditions studied: Propionic Acidemia

In brief

The objective of this project is to define whether nutritional supplements (ornithine alpha-ketoglutarate, glutamine, or citrate) capable of filling-up the citric acid cycle (anaplerotic therapy) can improve hyperammonemia, glutamine levels, and outcome in patients with propionic acidemia. Ornithine alpha-ketoglutarate, glutamine, and citrate are commonly used as nutritional supplements specially by athletes to increase muscle strength. They can be mixed with formula or other foods.

Key facts

Study ID

NCT00645879

Run by

Nicola Longo

People needed

3

Starts

2008-07-01

Expected to finish

2010-02-01

Last updated by the study team

2015-01-21

Who can join

Age: 5 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of propionic acidemia (propionyl CoA carboxylase deficiency)

You may not qualify if…

• Severe illness with cardiac or hepatic compromise that could affect study results
• Use of other investigative therapies
• Inability to comply with study directions

Where it is running

• University of Utah, Department of Pediatrics — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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