Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children

Withdrawn before enrolling

Conditions studied: Viral Pneumonia, Bacterial Pneumonia

In brief

The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose that the level of TREM-1 will be significantly elevated in the lung fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.

Key facts

Study ID

NCT00645619

Run by

University of Texas Southwestern Medical Center

People needed

0

Starts

2008-03-24

Expected to finish

2008-03-26

Last updated by the study team

2018-12-26

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children from birth to 18 years intubated for respiratory failure or for surgery as mentioned above within 48 hours of intubation.

You may not qualify if…

• Use of antibiotics >72 hours preceding the study (not applicable to the definite bacterial pneumonia group)
• Use of oral/parenteral glucocorticoid therapy <2 weeks prior to admission
• Presence of tracheostomy
• Active treatment for pulmonary arterial hypertension
• Mechanical ventilation with FIO2 >0.6, MAP>20
• Presence of severe pulmonary interstitial emphysema, pneumothorax, bradycardia (heart rate, <80 beats/min in neonates, <70 beats/min in infants), hypotension (mean arterial pressure, <40 mm Hg in neonates, <50 mm Hg in infants), and platelet count of <30,000/mm3.
• Immunodeficient or immunocompromised due to other conditions.
• Enrollment in another interventional study that employs BAL.

Where it is running

• Childrens Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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