Study Examing The Effect Of Omeprazole On Safety, Tolerability And How The Body Processes An Experimental Drug

Completed · Phase 1

Conditions studied: Obesity

In brief

Experiment in the test tube indicated that CP-945,598 becomes less soluble with increase of pH (less acidity). Changes in stomach acid levels may affect the solubility of CP-945,598, therefore, alters its availability in the blood. Omeprazole decreases acid levels in stomach. This study will compare the time course of drug concentrations in the body, safety, and tolerability of CP-945,598 given with and without omeprazole.

Key facts

Study ID

NCT00644839

Run by

Pfizer

People needed

28

Starts

2008-04-01

Expected to finish

2008-07-01

Last updated by the study team

2009-08-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Body Mass Index (BMI) of 26.6 to 40.5 kg/m2.

You may not qualify if…

• Non-prescribed use of drugs or abuse of recreational drugs; recent treatment with experimental drugs or herbal experiments; EKG and blood pressure measurements falling outside of protocol-specified limits; history of regular alcohol or tobacco use exceeding protocol-specified limits; medically important health conditions; recent use of prescription or non-prescription medications.

Where it is running

• Pfizer Investigational Site — Miami, Florida, United States

Full record on ClinicalTrials.gov

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