Tocolytics Trial: Intravenous (IV) Magnesium Versus Oral Nifedpine in Fetal Fibronectin (FFN) Postive Population

Stopped early · Phase 3

Conditions studied: Labor, Premature

In brief

In women with singleton gestations, to contemporarily assess the efficacy of oral nifedipine versus intravenous magnesium sulfate in the acute management of preterm labor in terms of defined early and late neonatal measures

Key facts

Study ID

NCT00641784

Run by

MemorialCare

People needed

200

Starts

2008-03-01

Expected to finish

2012-03-01

Last updated by the study team

2009-09-18

Who can join

Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients between 240/7-320/7 weeks gestation with findings consistent with preterm labor defined by at least one of the following criteria in accordance with regular uterine contractions (>4 uterine contractions in 20 minutes):
• Cervix > 2 cm in dilation or 80% effaced
• Positive fetal fibronectin (if performed).
• Demonstrated cervical change between two exams within 90 minutes.

You may not qualify if…

• Negative fetal fibronectin
• > 5cm dilatation
• Multiple gestations
• Known fetal anomalies or chromosomal abnormalities
• Ruptured membranes
• Significant vaginal bleeding
• Suspected chorioamnionitis
• Preeclampsia or uncontrolled hypertension
• Non-reassuring fetal heart tracing
• Placenta previa and/or accreta
• Placenta abruption
• Intrauterine growth restriction
• Maternal renal disease
• Underlying maternal cardiac condition
• Symptomatic hyperthyroidism
• Significant maternal disease
• Contraindication to nifedipine or magnesium
• Cerclage presence
• Tocolytic use within the last 12 hours
• Hypotension (defined as average blood pressure of <70/40's unresponsive to 1000 cc fluid bolus

Where it is running

• Memorial Care Center for Women/Long Beach Memorial Medical Center — Long Beach, California, United States

Full record on ClinicalTrials.gov

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