Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions

Status unconfirmed · Phase 4

Conditions studied: Atherosclerosis

In brief

Atherosclerosis is a disease in which the blood vessels become blocked by plaques (consisting of fat, calcification, and fibrous tissue), reducing blood flow to vital organs and tissues.Blockage of the carotid arteries in the neck is a major cause of stroke. One way of treating carotid atherosclerosis is with cholesterol-lowering drugs called statins. Statins have been shown to reduce the risk of coronary heart disease by 24-40% and risk pf stroke by 11-30%.The purpose of this study is to determine if short term treatment with atorvastatin causes early favorable changes in the plaques that block blood flow through the carotid arteries. These changes can be assessed 1) by taking pictures of the carotid arteries with MRI and Ultrasound before and after statin treatment, and 2) by special studies of the plaques removed from the carotid arteries by surgery.

Key facts

Study ID

NCT00640744

Run by

Baylor College of Medicine

People needed

12

Starts

2006-02-01

Expected to finish

2010-02-01

Last updated by the study team

2010-12-07

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men or women
• >18 yrs old
• Expected to have an endarterectomy on each carotid artery
• No contraindications for atorvastatin
• Stable cardiovascular health
• Lipid lowering treatment less than 6 mo duration
• Diabetic included if diabetes is controlled
• Patient is not claustrophobic
• Patient has evaluable carotid plaques.

You may not qualify if…

• Patient has had previous carotid endarterectomy,stenting, or other procedure
• Unstable cardiovascular status
• Hypersensitivity to statin therapy
• Neck anatomy preventing acquiring bilateral evaluable plaques
• Weight over 285 lbs.

Where it is running

• Baylor College of Medicine — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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